Viscosuplementación con ácido hialurónico de alto peso molecular doblemente reticulado en el tratamiento de la artrosis de rodilla. Estudio de su eficacia y seguridad

Abstract

ABSTRACT

Objectives: Osteoarthrosis (OA) is an incurable mono or polyarticular arthropathy and in the knee it is the most common degenerative disease with a high incidence of mechanical factors. The therapeutic arsenal for the management of knee OA (OAR) includes non-pharmacological and pharmacological measures, medication and intra-articular techniques, and surgery. The objectives of this study were to evaluate the efficacy in terms of pain, joint function and quality of life of patients infiltrated with double cross-linked high molecular weight (MW) hyaluronic acid (HA) (Cientific Synovial ® - CS -) as well as the safety of its use. Additionally, we tried to objectify the prosthesis-free time in patients with this indication. Methods: a pre - post design (single group) was carried out for patients with knee osteoarthritis. A sample of 46 patients (n = 46) was analyzed who were divided into two groups according to the Kellgren-Lawrence (KL) classification. A group KL 1-2 was infiltrated with HA 40 mg (CS40) and another group KL 3-4 was infiltrated with HA 60 mg (CS60). All patients filled out the KOOS12 questionnaire (Knee injury and Osteoarthritis Outcome Score) pre and post infiltration and appropriate descriptive and inferential statistics were performed. Conclusions: the double-crosslinked, high-MW HA (Cientific Synovial ®) improved statistically and clinically all the efficacy parameters analyzed using the KOOS12 questionnaire. The preparation was shown to be safe and without the appearance of significant adverse effects. Both in the patients with a previous indication for total knee replacement (TKR) rejected (n = 12), as in the rest of the patients in the sample, prosthesis-free survival was verified until the end of the study. Key words:Hyaluronic acid. Osteoarthritis of the knee. Viscosupplementation.